Shrivastava, R: Effect of Chromium Toxicity on Dengue Virus

Dengue is endemic all over India so is the occupational and non-occupational exposure to hexavalent chromium. The pathogenesis of dengue depends upon the immune response of the body. The intermediary products generated during reduction of chromium (VI) kill the target cells including leucocytes by apoptosis. This effect of chromium compromises the immune response of the host. It is, therefore, possible that the chromium toxicity may affect the disease process during dengue virus infection. There are no reports in literature on the outcome of dengue virus infections during chromium toxicity, therefore, this book is based on the experimental attempts which has been made to answer the some basic questions related to pathogenesis of dengue virus infections during chromium toxicity like What are the effects of subtoxic dose of Cr (VI) on the peripheral blood cells of mice during dengue virus infection? Does Cr (VI) toxicity enhance the ill effects of DV on splenic macrophage and lymphocyte functions? Can the cells of immune system detoxify Cr (VI)? etc.