Wibowo, I: Zebrafish lateral line system

The interaction and communication among cells are required for adaptability of cell movement and its consequence for tissue formation and remodeling, particularly in embryonic development and cancer metastasis. The purpose of this dissertation is to introduce and demonstrate several biological processes or phenomena using posterior lateral line system of zebrafish as a model. The first part of this work focuses on the highly dynamic tissue remodeling under the control of morphogenetic territories. In particular, eya1 gene is studied to add a susbtantial mechanism during migration of lateral line primordium. The second part of this dissertation mainly discusses about the existence of tissue compartment whereby Notch signaling involves in governing the regeneration anisotropy. This work is an intellectual collaboration with Filipe Pinto Sousa, a Ph.D. student in Dr. López-Schier laboratory. The last part of this dissertation emphasizes on the epigenetic study in order to validate the involvement of macroH2A during development of zebrafish embryos. This work is done in collaboration with Dr. Di Croce laboratory at the Centre for Genomic Regulation, Barcelona, Spain.